منابع مشابه
DNA fragment conformations in adducts with Kiteplatin.
The anticancer activity of cisplatin is triggered by its formation of intrastrand adducts involving adjacent G residues of DNA. To obtain information on the different conformers that can be formed, carrier ligands such as 2,2'-bipiperidine, which provide large steric bulk near the platinum coordination plane and decrease the dynamic motion about the Pt-N7 bonds, were introduced ("retro-modellin...
متن کاملConformations of Circular DNA
We examine the conformations of a model for short closed DNA. The molecule is represented as a cylindrically symmetric elastic string with a constraint corresponding to a specification of the linking number. We obtain analytic expressions for configuration, elastic energy, twist and linking number for a family of solutions spanning from a circle to a ’figure eight’. We suggest ways to use our c...
متن کاملConformations of Linear DNA
We examine the conformations of a model for underand overwound DNA. The molecule is represented as a cylindrically symmetric elastic string subjected to a stretching force and to constraints corresponding to a specification of the link number. We derive a fundamental relation between the Euler angles that describe the curve and the topological linking number. Analytical expressions for the spat...
متن کاملConformations of closed DNA.
We examine the conformations of a model for a short segment of closed DNA. The molecule is represented as a cylindrically symmetric elastic rod with a constraint corresponding to a specification of the linking number. We obtain analytic expressions leading to the spatial configuration of a family of solutions representing distortions that interpolate between the circular form of DNA and a figur...
متن کاملExploring polymorphisms in B-DNA helical conformations
The traditional mesoscopic paradigm represents DNA as a series of base-pair steps whose energy response to equilibrium perturbations is elastic, with harmonic oscillations (defining local stiffness) around a single equilibrium conformation. In addition, base sequence effects are often analysed as a succession of independent XpY base-pair steps (i.e. a nearest-neighbour (NN) model with only 10 u...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2005
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1982.tb06609.x